NOD proteins and immune response / 中国免疫学杂志

The NOD protein family include NOD1 and NOD2,both of which recognize intracellular bacterial peptidoglycan,induce inflammation and promote host defense.In this review article,we summarize the research progress on NOD family,including signaling and regulation.We will also discuss their cellular localization and the role in host defense.Understanding on their physiological function will help shed light on pathogenesis on related diseases.